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Publications
  • RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity. Sahoo, S., Nagraj, T., Bhattacharya, D., Somyajit, K., Nagaraju, G. (2024). (Communicated)
  • RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart. Bhattacharya, D., Dwivedi, H. K., Nagaraju, G. (2024). (Communicated)
  • RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes. Dixit, S., Nagraj, T.*, Bhattacharya, D.*, Saxena, S., Sahoo, S., Chittela R. K., Somyajit, K., Nagaraju, G. (2024). Cell Reports. [PubMed] (*Equal contribution)
  • RAD51 paralogs: Expanding roles in replication stress responses and repair. Bhattacharya, D., Sahoo, S., Nagraj, T., Dixit, S., Dwivedi, H. K., Nagaraju, G. (2022). Current Opinion in Pharmacology [PubMed]
  • Mycobacterium tuberculosis SufR responds to nitric oxide via its 4Fe–4S cluster and regulates Fe–S cluster biogenesis for persistence in mice. Anand, K., Tripathi, A., Shukla, K., Malhotra, N., Jamithireddy, A.K., Jha, R.K., Chaudhury, S.N., Rajmani, R.S., Ramesh, A., Nagaraja, V., Gopal, B. Nagaraju, G., Seshayee A.S.N., and Singh A. (2021). Redox Biology. [PubMed]
  • FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks. Nath, S. Nagaraju, G. (2020). PLoS Genetics. 16(4): e1008701. [PubMed]
  • ATR signaling uncouples the role of RAD51 paralogs in homologous recombination and replication stress response. Saxena, S., Dixit, S., Somyajit, K., and Nagaraju, G. (2019). Cell Reports. 29(3):551-559.e4. [PubMed]
  • Mycobacterium tuberculosis UvrD1 and UvrD2 helicases unwind G-quadruplex DNA. Saha, T., Shukla, K., Thakur, R.S., Desingu, A., and Nagaraju, G. (2019). FEBS J. 286:2062-2086. [PubMed]
  • XRCC2 regulates replication fork progression during dNTP alterations. Saxena, S., Somyajit, K., and Nagaraju, G. (2018). Cell Reports. 25:3273–3282 [PubMed]
  • RecGwed: A probable novel regulator in the resolution of branched DNA structures in Mycobacteria. Singh, A., Vijayan, M., and Nagaraju, G. (2018). IUBMB Life. 70(8):786-794. [PubMed]
  • RAD51C/XRCC3 facilitates mitochondrial DNA replication and maintains integrity of the mitochondrial genome. Mishra, A., Saxena, S., Kaushal, A., and Nagaraju, G. (2018). Mol. Cell. Biol. 38(3):1-18. [PubMed]
  • Escherichia coli and Neisseria gonorrhoeae UvrD helicase unwinds G4 DNA structures. Shukla, K., Thakur, R.S., Ganguli, D., Rao, D.N., and Nagaraju, G. (2017). Biochem J. 474(21):3579-3597. [PubMed]
  • FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids. Nath, S., Somyajit, K., Mishra, A., Scully, R., and Nagaraju, G. (2017). Nucleic Acids Res. 45(15):8886–8900. [PubMed]
  • Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand cross-linker for cancer therapy. Somyajit, K., Banik, B., Chakravarty, A.R., and Nagaraju, G. (2016). Carcinogenesis 37(2):145-56. [PubMed]
  • Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. Somyajit, K., Saxena, S., Babu, S., Mishra, A., and Nagaraju, G. (2015). Nucleic Acids Res. 43(20):9835-55. [PubMed]
  • Mycobacterium tuberculosis RecG but not RuvAB or RecA is efficient at remodeling the stalled replication forks: Implications for multiple mechanisms of replication restart in mycobacteria. Thakur, R.S., Basavaraju, S., Khanduja, J.S., Muniyappa, K., and Nagaraju, G. (2015). J. Biol. Chem. 290.40: 24119-24139. [PubMed]
  • Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation. Naveenkumar, S. K., Thushara, R.M., Sundaram, M.S., Hemshekar, M., Paul, M., Thirunavukkarasu, C., Basappa., Nagaraju, G., Raghavan, S.C., Girish, K.S., Kemparaju, K. and Rangappa, K.S. (2015). Scientific Reports 5:15045. [PubMed]
  • Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide. Paul, M., Hemshekhar, M., Thushara, R.M., Sundaram, M.S., NaveenKumar, S.K., Naveen, S., Devaraja, S., Somyajit, K., West, R., BasappaNayaka, S.C., Zakai, U.I., Nagaraju, G., Rangappa, K.S., Kemparaju, K., and Girish, K.S. (2015). PLoS One 10: e0127558. [PubMed]
  • Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase (PARP). Somyajit, K., Mishra, A., Jameei, A., and Nagaraju, G. (2015). Carcinogenesis 36:13-24. [PubMed]
  • Mycobacterium tuberculosis DinG is a structure specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach. Thakur, R.S., Desingu, A., Basavaraju, S., Subramanya, S., Rao, D.N., and Nagaraju, G. (2014) J. Biol. Chem. 289: 25112-36. [PubMed]
  • Oxovanadium(IV) catecholates of terpyridine bases for cellular imaging and photocytotoxicity in red light. Banik, B., Somyajit, K., Nagaraju, G., and Chakravarty, A.R. (2014). RSC Advances 75: 40120-31.
  • Oxovanadium(iv) complexes of curcumin for cellular imaging and mitochondria targeted photocytotoxicity. Banik, B., Somyajit, K., Nagaraju, G., and Chakravarty, A.R. (2014). Dalton Trans. 43: 13358-69. [PubMed]
  • Carbohydrate-appended photocytotoxic (imidazophenanthroline) oxovanadium (IV) complexes for cellular targeting and imaging. Banik, B., Somyajit, K., Hussain, A., Nagaraju, G., and Chakravarty, A.R. (2014). Dalton Trans. 43:1321-31. [PubMed]
  • ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double strand break-induced checkpoint activation and repair. Somyajit, K., Basavaraju, S., Scully, R. and Nagaraju, G. (2013). Mol. Cell. Biol. 33:1830-44. [PubMed]
  • Evidence for the role of Mycobacterium tuberculosis RecG helicase in DNA repair and recombination. Thakur, R.S, Basavaraju, S., Somyajit, K., Jain, A., Subramanya, S., Muniyappa, K. and Nagaraju, G. (2013). FEBS J. 280:1841-60. [PubMed]
  • Enhancing the photocytotoxic potential of curcumin on terpyridyl lanthanide (iii) complex formation. Hussain A, Somyajit K, Banik B, Banerjee S, Nagaraju G, Chakravarty AR (2013). Dalton Trans. 42:182-95. [PubMed]
  • Photoactivated DNA cleavage and anticancer activity of oxovanadium(IV) complexes of curcumin. Balaji, B., Somyajit, K., Banik, B., Nagaraju, G., and Chakravarty, A.R. (2013). Inorganica Chimica Acta 400: 142–150.
  • Cellular uptake and remarkable photocytotoxicity of pyrenylter pyridine oxovanadium(IV) complexes of dipyridophenazine bases. Banik, B., Somyajit, K., Koley, D., Nagaraju, G., and Chakravarty, A.R. (2012). Inorganica Chimica Acta 393: 284–293.
  • Distinct roles of FANCO/RAD51C in DNA damage signaling and repair: Implications for Fanconi anemia and breast cancer susceptibility. Somyajit, K., Subramanya, S., and Nagaraju, G. (2012). J. Biol. Chem. 287: 3366-3380. [PubMed]
  • RAD51 as a potential biomarker and therapeutic target for pancreatic cancer. Nagaraj, N. S., and Nagaraju, G. (2011). BBA Reviews on Cancer 1816: 209-218. [PubMed]
  • RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. Somyajit, K., Subramanya, S., and Nagaraju, G. (2010). Carcinogenesis 31: 2031-2038. [PubMed]
  • XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversion between sister chromatids. Nagaraju, G., Hartlerode, A., Kwok, A., Chandramouly, G., and Scully, R. (2009). Mol. Cell Biol. 29: 4283-4294. [PubMed]
  • Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Xie, A., Hartlerode, A., Stucki, M., Odate, S., Puget, N., Nagaraju, G., Yan, C., Alt, F.W., Chen, J., Jackson, S.P., and Scully, R. (2007). Mol. Cell 28: 1045-1057. [PubMed]
  • Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks. Nagaraju, G., and Scully, R. (2007). DNA Repair 6: 1018-1031. [PubMed]
  • Differential Regulation of Short- and Long-Tract Gene Conversion between Sister Chromatids by Rad51C. Nagaraju, G., Odate, S., Xie, A., and Scully, R. (2006). Mol Cell Biol. 26: 8075-8086. [PubMed]
  • Molecular functions of BRCA1 in the DNA damage response. Scully, R., Xie, A., Nagaraju, G. (2004). Cancer Biol Ther. 6: 521-527. [PubMed]
  • Mycobacterium smegmatis RecA protein is structurally similar to but functionally distinct from Mycobacterium tuberculosis RecA. N. Ganesh and K. Muniyappa. (2003). PROTEINS 53: 6-17. [PubMed]
  • Characterization of DNA strand transfer promoted by Mycobacterium smegmatis RecA reveals functional diversity with Mycobacterium tuberculosis RecA. N. Ganesh and K. Muniyappa. (2003). Biochemistry 42:7216-7225. [PubMed]
  • Crystal structures of Mycobacterium smegmatis RecA and its nucleotide complexes. S. Datta, R. Krishna, N. Ganesh, Nagasuma R. Chandra, K.Muniyappa and M. Vijayan. (2003). J. Bacterial. 185: 4280-4284. [PubMed]
  • Homologous recombination in mycobacteria. K. Muniyappa, N. Ganesh, N. Guhan, Pawan Singh, G. P. Manjunath , S. Datta, Nagasuma R.Chandra and M. Vijayan. (2003). CURRENT SCIENCE 86: 141-148.
  • Structural studies on MtRecA-nucleotide complexes: Insights into DNA and nucleotide binding and the structural signature of NTP recognition. S. Datta, N. Ganesh, Nagasuma R. Chandra, K. Muniyappa and M.Vijayan. (2003) PROTEINS 50: 474- 485. [PubMed]
  • RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: Insights into negative regulation of homologous recombination. R. Venkatesh*, N. Ganesh*, N. Guhan*, M. Sreedhar Reddy*, T. Chandrasekar and K. Muniyappa. (2002). Proc. Natl. Acad. Sci. USA 99:12091-12096. (* These authors contributed equally) [PubMed]
  • Crystal Structure of Mycobacterium tuberculosis RecA and its complex with ADP- AIF 4: implications for decreased ATPase activity and molecular aggregation. S. Datta, Prabhu. M. M, Vaze. M. B, Ganesh. N., Chandra. N. R., Muniyappa. K. and Vijayan. M. (2000). Nucleic Acids Res. 28, 4964- 4973. [PubMed]
  • Comparitive genomics of Mycobacterium tuberculosis and Escherichia coli for recombination (rec) genes. Muniyappa .K., Vaze. M. B., Ganesh. N., Reddy. M. S., Guhan. N., Venkatesh. R. (2000). Microbiology 146, 2093-2095. [PubMed]
Copyright © 2016, BICS, Dept. of Biochemistry, IISc, Bengaluru - 560012.