Prof. Utpal Tatu's Lab

1. Beri, D., B. Balan, S. Chaubey, S. Subramaniam, B. Surendra, and U. Tatu. 2017. A disrupted transsulphuration pathway results in accumulation of redox metabolites and induction of gametocytogenesis in malaria. Sci Rep 7:40213,https://doi.org/10.1038/srep40213

2. Raman, S., Singh, M., Tatu, U., Suguna, K. (2015). First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90. Sci Rep. 2015 Nov 24;5:17015, https://doi.org/10.1038/srep17015

3. Singh, M., Sharma, S., Bhattacharya, A., & Tatu, U. (2015). Heat Shock Protein 90 regulates encystation in Entamoeba. Frontiers in Microbiology, 6, 1125, https://doi.org/10.3389/fmicb.2015.01125

4. Chatterjee S, Alampalli SV, Nageshan RK, Chettiar ST, Joshi S, Tatu US. Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris. BMC Genomics. 2015 Sep 7;16(1):686, https://doi.org/10.1186/s12864-015-1863-z.

5. Nageshan RK, Roy N, Ranade S, Tatu U. Trans-spliced heat shock protein 90 modulates encystation in Giardia lamblia. PLoS Negl Trop Dis. 2014 May 1;8(5):e2829, https://doi.org/10.1371/journal.pntd.0002829

6. Chaubey S, Grover M, Tatu U. Endoplasmic reticulum stress triggers gametocytogenesis in the malaria parasite. J Biol Chem. 2014 Jun 13;289(24):16662-74, doi: 10.1074/jbc.M114.551549

7. Singh M, Shah V, Tatu U. A novel C-terminal homologue of Aha1 co-chaperone binds to heat shock protein 90 and stimulates its ATPase activity in Entamoeba histolytica. J Mol Biol. 2014 Apr 17;426(8):1786-98,https://doi.org/10.1016/j.jmb.2014.01.008

8. Nageshan RK, Roy N, Hehl AB, Tatu U. Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing. J Biol Chem. 2011 Mar 4;286(9):7116-22, https://doi.org/10.1074/jbc.C110.208389

9. Dolgin E, Motluk A. Heat shock and awe. Nat Med. 2011 Jun;17(6):646-9. (An editorial which comments on the work from the lab on Heat shock proteins as a target for treating infectious diseases.), https://doi.org/10.1038/nm0611-646

10. Pallavi R, Roy N, Nageshan RK, Talukdar P, Pavithra SR, Reddy R, Venketesh S, Kumar R, Gupta AK, Singh RK, Yadav SC, Tatu U. Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. J Biol Chem. 2010 Dec 3;285(49):37964-75, https://doi.org/10.1074/jbc.M110.155317

11. Roy N, Nageshan RK, Pallavi R, Chakravarthy H, Chandran S, Kumar R, Gupta AK, Singh RK, Yadav SC, Tatu U. Proteomics of Trypanosoma evansi infection in rodents. PLoS One. 2010 Mar 22;5(3):e9796, https://doi.org/10.1371/journal.pone.0009796

12. Wider D, Péli-Gulli MP, Briand PA, Tatu U, Picard D. The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities. Mol Biochem Parasitol. 2009 Apr;164(2):147-52, https://doi.org/10.1016/j.molbiopara.2008.12.011

13. Neckers L, Tatu U. Molecular chaperones in pathogen virulence: emerging new targets for therapy. Cell Host Microbe. 2008 Dec 11;4(6):519-27, https://doi.org/10.1016/j.chom.2008.10.011

14. Selvaraj SR, Bhatia V, Tatu U. Oxidative folding and assembly with transthyretin are sequential events in the biogenesis of retinol binding protein in the endoplasmic reticulum. Mol Biol Cell. 2008 Dec;19(12):5579-92, https://doi.org/10.1091/mbc.e08-01-0026

15. Sawarkar R, Roy N, Rao S, Raman S, Venketesh S, Suguna K, Tatu U. Heat shock protein 90 regulates development in Dictyostelium discoideum. J Mol Biol. 2008 Oct 31;383(1):24-35, https://doi.org/10.1016/j.jmb.2008.08.006

16. Khachane A, Kumar R, Jain S, Jain S, Banumathy G, Singh V, Nagpal S, Tatu U. "Plasmo2D": an ancillary proteomic tool to aid identification of proteins from Plasmodium falciparum. J Proteome Res. 2005 Nov-Dec;4(6):2369-74, https://doi.org/10.1021/pr050289p

17. Pavithra SR, Banumathy G, Joy O, Singh V, Tatu U. Recurrent fever promotes Plasmodium falciparum development in human erythrocytes. J Biol Chem. 2004 Nov 5;279(45):46692-9, https://doi.org/10.1074/jbc.M409165200

18. Kumar Y, Khachane A, Belwal M, Das S, Somsundaram K, Tatu U. ProteoMod: A new tool to quantitate protein post-translational modifications. Proteomics. 2004 Jun;4(6):1672-83, https://doi.org/10.1002/pmic.200300778

19. Kumar Y, Tatu U. Stress protein flux during recovery from simulated ischemia: induced heat shock protein 70 confers cytoprotection by suppressing JNK activation and inhibiting apoptotic cell death. Proteomics. 2003 Apr;3(4):513-26, https://doi.org/10.1002/pmic.200390065

20. Banumathy G, Singh V, Pavithra SR, Tatu U. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J Biol Chem. 2003 May 16;278(20):18336-45, https://doi.org/10.1074/jbc.M211309200

21. Banumathy G, Singh V, Tatu U. Host chaperones are recruited in membrane-bound complexes by Plasmodium falciparum. J Biol Chem. 2002 Feb 8;277(6):3902-12, https://doi.org/10.1074/jbc.M110513200