Trypanosomiasis
Surra is caused by Trypanosoma evansi infection. It is a veterinary protozoan disease most common in the cows, buffaloes, horses and other cattle. The disease has been listed as one of the major concern by World Organisation for Animal Health (OIE) in 2011 and is common in tropical countries. My laboratory works on understanding the role of chaperones in the progress of disease in host. We have shown important role of Heat Shock Protein 90 from T. evansi (TeHsp90) by using Hsp90 directed inhibitor called 17-AAG (17-allyl amino 17-demethoxy geldanamycin). We are now progressing towards starting animal trials against the disease using the above mentioned inhibitors.(Pallavi R et al., JBC 2010, Roy N et al., Plos One 2010)
