Research
The enzymes involved in the restriction-modification system in Heliobacter pylori and the mismatch repair system from Neisseria
gonorrhoea. The mechanisms by which methanol activates the alcohol oxidase promoter in Pichia pastoris. Mitochondrial protein translocation, biogenesis and turnover with regard to various pathophysiological conditions. The roles of heat shock proteins (HSPs) and mechanisms regulating gametocytogenesis in malaria are being investigated. In addition, neglected infectious diseases are being studied to
improve diagnosis and treatment strategies.
Enzyme and Metabolic Engineering
Protein Folding and Trafficking
The molecular mechanisms underlying chromosome synapsis, homologous recombination, DNA repair and genomic stability. Studies on RAD51 paralogs in mammalian DNA damage responses, genome stability and tumor suppression. The roles of the Structural Maintenance of Chromosomes (SMC) complexes that mediate higher order chromatin organization. The roles of RAG proteins in genomic instability, understanding mechanism of non-homologous end joining (NHEJ) and identification of compounds with anti-cancer properties. Understanding the basis of mRNA fate decisions with a specific focus on translation and mRNA decay. The mechanisms that operate during translational readthrough. The formation of new blood vessels, i.e. angiogenesis, is being studied with regard to the effects of low energy shock waves.
DNA Repair and Genome Stability
Cancer Biology
Eukaryotic Gene Expression
Post-Transcriptional Gene Control
Mathematical and computational models of biological systems are being studied to understand control structures in biochemical pathways,
metabolic and regulatory networks, insights from which are being used to understand key perturbations in disease and for biomarker and drug discovery as well as precision medicine. Several algorithms have been developed to probe protein structures and genome-wide molecular interaction networks.
The host response during infection is an important area of research. In this regard, two aspects i.e. thymic atrophy and sepsis during
infections are being investigated. Using an integrated systems biology approach, host response to tuberculosis is being investigated.